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MNHN, Musée de l’Homme, 17 Place du Trocadéro

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Assistant Professor

Univ Paris Diderot - Paris 7



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Research Team

Evolutionary Anthropology


  • 2001-present
    Assistant Professor, Univ Paris Diderot, Laboratoire Eco-Anthropologie et Ethnobiologie, CNRS, MNHN, Paris, France
  • 2017
    Habilitation à Diriger des Recherches, Univ Paris Diderot
  • 1999-2001
    Postdoctoral researcher with Evelyne Heyer at Laboratoire Anthropologie Biologique, Musée de l’Homme, MNHN, Paris, France
  • 1997-1999
    Teaching and Research Temporary Attaché (ATER), Univ Paris-Sud 11, Orsay, France
  • 1994-1998
    PhD thesis with Bernard Godelle and Pierre-Henri Gouyon at Laboratoire Ecologie, Systématique et Evolution, Univ Paris-Sud 11, Orsay, France
  • 1993-1994
    Scientifique du contingent at Laboratoire Bioénergétique, CEA, Saclay, France
  • 1990-1993
    Institut National Agronomique Paris-Grignon (INA-PG - AgroParisTech), Paris, France


  • Probability
  • Biostatistics
  • Population Genetics
  • Molecular Evolution
  • Phylogeny


PhD Students

  • 2012-2015 : Elise A. Lucotte
  • 2010-2013 : Romain Laurent (co-supervision with Raphaëlle Chaix)
  • 2008-2011 : Jean-Tristan Brandenburg (co-supervision with Frédéric Austerlitz)



  • Ly G, Alard B, Laurent R, Lafosse S, Toupance B, Monidarin C, Diffloth G, Bourdier F, Evrard O, Pavard S, Chaix R (2018)
    Residence rule flexibility and descent groups dynamics shape uniparental genetic diversities in South East Asia.
    Am-J-Phys-Anthropol 165 : 480-491
    [DOI:10.1002/ajpa.23374] [PMID:29359511]
  • Lucotte EA, Laurent R, Heyer E, Ségurel L, Toupance B (2016)
    Detection of Allelic Frequency Differences between the Sexes in Humans : A Signature of Sexually Antagonistic Selection.
    Genome-Biol-Evol 8 : 1489-1500
    [DOI:10.1093/gbe/evw090] [PMID:27189992]
  • Heyer E, Brandenburg JT, Leonardi M, Toupance B, Balaresque P, Hegay T, Aldashev A, Austerlitz F (2015)
    Patrilineal populations show more male transmission of reproductive success than cognatic populations in Central Asia, which reduces their genetic diversity.
    Am-J-Phys-Anthropol 157 : 537-543
    [DOI:10.1002/ajpa.22739] [PMID:25821184]
  • Enaud L, Hadchouel A, Coulomb A, Berteloot L, Lacaille F, Boccon-Gibod L, Boulay V, Darcel F, Griese M, Linard M, Louha M, Renouil M, Rivière JP, Toupance B, Verkarre V, Delacourt C, de Blic J (2014)
    Pulmonary alveolar proteinosis in children on La Réunion Island : a new inherited disorder ?
    Orphanet-J-Rare-Dis 9 : 85
    [DOI:10.1186/1750-1172-9-85] [PMID:24927752]
  • Ségurel L, Austerlitz F, Toupance B, Gautier M, Kelley JL, Pasquet P, Lonjou C, Georges M, Voisin S, Cruaud C, Couloux A, Hegay T, Aldashev A, Vitalis R, Heyer E (2013)
    Positive selection of protective variants for type 2 diabetes from the Neolithic onward : a case study in Central Asia.
    Eur-J-Hum-Genet 21 : 1146-1151
    [DOI:10.1038/ejhg.2012.295] [PMID:23340510]
  • Brandenburg JT, Austerlitz F, Toupance B (2012)
    Impact of fertility transmission and other sociodemographic factors on reproductive success and coalescent trees.
    Genet-Res-Camb 94 : 121-131
    [DOI:10.1017/S0016672312000298] [PMID:22647505]
  • Manni F, Heeringa W, Toupance B, Nerbonne J (2008)
    Do surname differences mirror dialect variation ?
    Hum-Biol 80 : 41-64
  • Gagnon A, Toupance B, Tremblay M, Beise J, Heyer E (2006)
    Transmission of migration propensity increases genetic divergence between populations.
    Am-J-Phys-Anthropol 129 : 630-636
    [DOI:10.1002/ajpa.20330] [PMID:16342261]
  • Yotova V, Labuda D, Zietkiewicz E, Gehl D, Lovell A, Lefebvre JF, Bourgeois S, Lemieux-Blanchard E, Labuda M, Vézina H, Houde L, Tremblay M, Toupance B, Heyer E, Hudson TJ, Laberge C (2005)
    Anatomy of a founder effect : myotonic dystrophy in Northeastern Quebec.
    Hum-Genet 117 : 177-187
    [DOI:10.1007/s00439-005-1298-8] [PMID:15883838]
  • Manni F, Toupance B, Sabbagh A, Heyer E (2005)
    New method for surname studies of ancient patrilineal population structures, and possible application to improvement of Y-chromosome sampling.
    Am-J-Phys-Anthropol 126 : 214-228
    [DOI:10.1002/ajpa.10429] [PMID:15386234]
  • Balaresque P, Toupance B, Quintana-Murci L, Crouau-Roy B, Heyer E (2004)
    Sex-specific selection on the human X chromosome ?
    Genet-Res 83 : 169-176
  • Heyer E, Toupance B, Perri C, De Vito O, Foncin JF, Cecilia Bruni A (2003)
    Manic depressive illness in a founder population.
    Eur-J-Hum-Genet 11 : 597-602
    [DOI:10.1038/sj.ejhg.5201001] [PMID:12891380]
  • Gagnon A, Toupance B (2002)
    Testing isonymy with paternal and maternal lineages in the early Québec population : the impact of polyphyletism and demographic differentials.
    Am-J-Phys-Anthropol 117 : 334-341
    [DOI:10.1002/ajpa.10059] [PMID:11920369]
  • Le Thierry d’Ennequin M, Panaud O, Toupance B, Sarr A (2000)
    Assessment of genetic relationships between Setaria italica and its wild relative S. viridis using AFLP markers.
    Theor-Appl-Genet 100 : 1061-1066
  • Le Thierry d’Ennequin M, Toupance B, Robert T, Godelle B, Gouyon PH (1999)
    Plant domestication : a model for studying the selection of linkage.
    J-Evol-Biol 12 : 1138-1147
  • Tenaillon O, Toupance B, Le Nagard H, Taddei F, Godelle B (1999)
    Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria.
    Genetics 152 : 485-493
  • Toupance B, Godelle B, Gouyon PH, Schächter F (1998)
    A model for antagonistic pleiotropic gene action for mortality and advanced age.
    Am-J-Hum-Genet 62 : 1525-1534
    [DOI:10.1086/301865] [PMID:9585593]
  • Taddei F, Radman M, Maynard-Smith J, Toupance B, Gouyon PH, Godelle B (1997)
    Role of mutator alleles in adaptive evolution.
    Nature 387 : 700-702
    [DOI:10.1038/42696] [PMID:9192893]
  • Leibl W, Toupance B, Breton J (1995)
    Photoelectric characterization of forward electron transfer to iron-sulfur centers in photosystem I.
    Biochemistry 34 : 10237-10244

*These authors contributed equally to the paper.